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Relevant Publications

At AccuBeing, our experts have years of experience in the cancer treatment field making scientific discoveries. Below are some selected publications highlighting their work.

1. Gene Expression Profiling of Gastrointestinal Malignancies.

  • Hsu, DS, et al. Immune Signatures Predict Prognosis in Localized Cancer. Cancer Investigation (2010), Aug;28(7):765-73. (PMC4486063)
  •  Levine, EA, et al... Hsu, DS. Gene Expression Profiling of Peritoneal Metastases from Appendiceal and Colon Cancer Demonstrates Unique Biologic Signatures and Predicts Patient Outcomes. J Am Coll Surg. 2012 Feb 16. (PMC3768122)
  • 2. Development of Patient Derived Xenografts as preclinical model of solid tumors

  •  Kim, MK, et al... and Hsu, DS. Characterization of an Oxaliplatin Sensitivity Predictor in a preclinical Murine Model of Colorectal Cancer. Mol Cancer Ther. 2012 Jul;11(7):1500-9. Epub 2012 Feb 16 (PMC4521598).
  •  Uronis, JM, et al... and Hsu, DS. Histological and Molecular Evaluation of Patient-Derived Colorectal Cancer Explants. PloS One, 2012;7(6):e38422. Epub 2012 Jun 4 (PMC2266969)
  • 3. GI Cancer Clinical Trials

  •  Uronis HE, ... Hsu DS, et al. A phase II study of capecitabine, oxaliplatin, and bevacizumab in the treatment of metastatic esophagogastric adenocarcinomas. Oncologist. 2013;18(3):271-2. Epub 2013 Mar 13 (PMID: 23485624).
  •  Morse MA, ... Hsu DS, et al. Novel adenoviral vector induces T-cell responses despite anti-adenoviral neutralizing antibodies in colorectal cancer patients. Cancer Immunol Immunother. 2013 Apr 30. (PMC3607522).
  •  Strickler JH, ... b>Hsu DS, et al. Phase I study of dasatinib in combination with capecitabine, oxaliplatin and bevacizumab followed by an expanded cohort in previously untreated metastatic colorectal cancer. Invest New Drugs. 2014 Apr;32(2):330-9. (PMC4108590).
  •  Morse, MA, ... Hsu DS, et al. A Randomized Phase II Study of Immunization With Dendritic Cells Modified With Poxvectors Encoding CEA and MUC1 Compared With the Same Poxvectors Plus GM-CSF for Resected Metastatic Colorectal Cancer. Ann Surg. 2013 Dec;258(6):879-86 (PMC3812362).
  • 4. Cancer Metastasis Models

  •  Chen, HJ, et al... b>Shen, X*, and Lipkin, S. (2012). Chemokine 25-induced signaling suppresses colon cancer invasion and metastasis. The Journal of Clinical Investigation, 122(9), 3184-96. PMCID: PMC3428084. * Equal corresponding author.
  •  Chen, HJ, et al... Shen, X*, and Lipkin, S., M. (2015) Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting. Nature Biotechnology, 33,656... 60 PMCID: PMC4532544 * Equal
  •  Li J, et al,... Shen, X, King MR. (2016) Targeted drug delivery to circulating tumor cells via platelet membrane-functionalized particles. Biomaterials. 76:52-65. doi: 10.1016/j.biomaterials.2015.10.046.
  •  Chen, HJ,... Shen, X, et al. (2016) A recellularized human colon model identifies cancer driver genes. Nature Biotechnology. 34, 845-851 doi: 10.1038/nbt.3586.
  •  Bu, P, et al... and Shen, X. (2015) miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β. Nature Communications, 6:6879. PMCID: PMC4399006 corresponding author.
  • 5. Cancer Stem Cells and Signaling

  •  Bu, P, et al... and Shen, X. (2013). A microRNA miR-34a-regulated bimodal switch targets Notch in colon cancer stem cells. Cell Stem Cell, 12(5), 602-15. PMCID: PMC3646336.
  •  Bu, P, et al... Shen, X. (2016) A miR-34a-Numb feed-forward loop triggered by inflammation regulates asymmetric stem cell division in intestine and colon cancer. Cell Stem Cell, 18(2), 189-202. doi: 10.1016/j.stem.2016.01.006
  •  Srinivasan, T, et al... and Shen, X. (2016) NOTCH Signaling Regulates Asymmetric Cell Fate of Fast- and Slow-Cycling Colon Cancer Initiating Cells. Cancer Research, 10.1158/0008-5472.CAN-15-3198.
  •  Wang, L, et al... b>Shen, X. (2016) A Long Non-Coding RNA Targets MicroRNA miR-34a to Regulate Colon Cancer Stem Cell Asymmetric Division. eLife 2016;10.7554/eLife.14620
  •  Wang Y, ... b>Shen, X, et al. (2016) Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma. Gastroenterology, pii: S0016-5085(16)35029-6. doi: 10.1053/j.gastro.2016.09.004.
  •  Klose, C, ... Shen, X, et al. (2017). Neuronal regulation of innate lymphoid cells controls type 2 inflammation. Nature, 549(7671):282-286 06 Sep 2017.